10-year risk of severe GI bleeds
>12%-15%
>9%-12%
>6%-9%
>3%-6%
0%-3%
0% -5%>5% -10%>10% -15%>15% -20%>20% -25%
10-year risk of Ml

Benefit Harm chart for low dose aspirin for the primary prevention
of cardiovascular disease and cancer

Welcome to the online calculator for estimating the benefit harm balance of low dose aspirin for primary prevention of cardiovascular disease and cancer. The benefit harm chart shows, per women and men, age category and according to 10-year outcome risks of myocardial infarction and severe gastrointestinal bleeds the likelihood that the benefits (prevention of severe ischemic stroke, myocardial infarction and cancers) are greater than the harms (severe hemorrhagic stroke and severe gastrointestinal bleeds). The quantitative benefit harm analyses underlying this benefit harm chart are reported in Puhan et al. BMC Medicine 2015, 13:250 doi:10.1186/s12916-015-0493-2 http://www.biomedcentral.com/1741-7015/13/250

Individuals have different values and preferences. For some, it is much more important to avoid a severe stroke, myocardial infarction or cancer than suffering from a severe gastrointestinal bleed. Others may not want to have an increased risk for severe gastrointestinal bleeds in order to reduce the chance of a severe stroke, myocardial infarction or cancer.

This online tool shows how preferences for outcomes have an impact on the benefit harm balance of low dose aspirin. The green color indicates that the benefits of aspirin exceed the harms, red means that the harms exceed the benefits and orange means that the benefits and harms are likely to be similar.


Please indicate if you are interested in benefit harm balance for women or for men

Please indicate if you are interested in a particular age category

Please indicate how important you perceive severe strokes, myocardial infarctions, severe gastrointestinal bleeds and cancers relative to one another. Please use the sliders to change the importance of these outcomes from your perspective. The starting positions of the sliders reflect the 5-year survival associated with these outcomes (higher number for lower survival). Please note that your perspective on the importance of these outcomes may not only consider survival but may also be influenced by your expected quality of life when living with one of these outcomes and short- and long-term treatments to treat them.
 

Not important Extremely important
Severe strokes
Myocardial infarctions
Severe gastro-intestinal bleeds
Not important Extremely important
Not important Extremely important
Very severe cancers
Severe cancers
Moderately severe cancers
Not important Extremely important
Click on table for details
10-year risk for severe GI bleed in %
10-year risk for MI in %
Age 45-54
>12%-15%     
>9%-12%     
>6%-9%     
>3%-6%     
0%-3%     
0% -5%>5% -10%>10% -15%>15% -20%>20% -25%
Age 55-64
>12%-15%     
>9%-12%     
>6%-9%     
>3%-6%     
0%-3%     
0% -5%>5% -10%>10% -15%>15% -20%>20% -25%
Age 65-74
>12%-15%     
>9%-12%     
>6%-9%     
>3%-6%     
0%-3%     
0% -5%>5% -10%>10% -15%>15% -20%>20% -25%
Age 75-84
>12%-15%     
>9%-12%     
>6%-9%     
>3%-6%     
0%-3%     
0% -5%>5% -10%>10% -15%>15% -20%>20% -25%